THE FMS-LIKE TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR

被引：1831

作者：

DEVRIES, C

ESCOBEDO, JA

UENO, H

HOUCK, K

FERRARA, N

WILLIAMS, LT

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,CARDIOVASC RES INST,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,HOWARD HUGHES MED INST,SAN FRANCISCO,CA 94143

[3] GENENTECH INC,DEPT CARDIOVASC RES,S SAN FRANCISCO,CA 94080

来源：

SCIENCE | 1992年 / 255卷 / 5047期

关键词：

D O I：

10.1126/science.1312256

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The fms-like tyrosine kinase (Flt) is a transmembrane receptor in the tyrosine kinase family. Expression of flt complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF), a factor that induces vascular permeability when injected in the guinea pig skin and stimulates endothelial cell proliferation. Expression of Flt in Xenopus laevis oocytes caused the oocytes to release calcium in response to VEGF-VPF. These findings show that flt encodes a receptor for VEGF-VPF.

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页码：989 / 991

页数：3

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