ENHANCED RESPONSE TO DAUNOMYCIN OF NORMAL, TUMOR AND METASTATIC CELL-LINES VIA DRUG PHOTOACTIVATION

被引：11

作者：

ANDREONI, A

COLASANTI, A

KISSLINGER, A

MASTROCINQUE, M

PORTELLA, G

RICCIO, P

ROBERTI, G

机构：

[1] UNIV NAPLES,DIPARTIMENTO BIOL & PATOL CELLULARE & MOLEC,I-80131 NAPLES,ITALY

[2] FDN SEN G PASCALE,IST NAZL STUDIO & CURA TUMORI,I-80131 NAPLES,ITALY

[3] UNIV NAPLES,DIPARTIMENTO SCI FIS,I-80125 NAPLES,ITALY

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1993年 / 57卷 / 05期

关键词：

D O I：

10.1111/j.1751-1097.1993.tb09223.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have compared the cytotoxicity of daunomycin in vitro to highly differentiated normal epithelial cells (Fisher rat thyroid cells, FRTL-5) and to two neoplastic cell lines, a thyroid carcinoma (TK-6) and its lung metastasis (MPTK-6). Whereas the cell lines are equally sensitive to the drug in the dark, if irradiated during incubation with daunomycin (86 J/CM2 at 488 nm), they become more and differently sensitive. Namely, the drug doses producing 50% mortality decrease by factors of about 22, 28 and 16 for FRTL-5, TK-6 and MPTK-6 cell lines, respectively. This result correlates with differences in drug uptake and resistance observed in the normal and neoplastic cell lines.

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页码：851 / 855

页数：5

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