DOUBLE-BLIND, RANDOMIZED, CONTROLLED CLINICAL-TRIAL OF NORFLOXACIN FOR CHOLERA

被引：29

作者：

BHATTACHARYA, SK ^{[1
]}

BHATTACHARYA, MK ^{[1
]}

DUTTA, P ^{[1
]}

DUTTA, D ^{[1
]}

DE, SP ^{[1
]}

SIKDAR, SN ^{[1
]}

MAITRA, A ^{[1
]}

DUTTA, A ^{[1
]}

PAL, SC ^{[1
]}

机构：

[1] INFECT DIS HOSP,CALCUTTA,INDIA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 05期

关键词：

D O I：

10.1128/AAC.34.5.939

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In a double-blind, randomized clinical trial with 78 adults with watery diarrhea and severe dehydration, 37 subjects were positive for Vibrio cholerae. In conjunction with rehydration therapy, 13 patients received norfloxacin, 12 received trimethoprim-sulfamethoxazole (TMP-SMX), and 12 received a placebo. Norfloxacin was superior to TMP-SMX and to the placebo in reducing stool output, duration of diarrhea, fluid requirements, and vibrio excretion. TMP-SMX was no better than the placebo.

引用

页码：939 / 940

页数：2

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