MICHAELIS-MENTEN PHARMACOKINETICS OF PHENYTOIN IN ADULT MALAYSIAN PATIENTS

被引：0

作者：

ISMAIL, R

RAHMAN, AFA

机构：

来源：

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 1990年 / 15卷 / 06期

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暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We reviewed our data from 122 records of patients taking phenytoin for the treatment of various types of epilepsy and selected 15 (age range 10-43 years old) who were on phenytoin alone to calculate Michaelis-Menten pharmacokinetic parameters. The average V(m) and K(m) for this age group was found to be 8.45 mg/kg/day and 6.72 mg/litre, respectively. K(m) was independent of age and weight. V(m) correlated well with weight but there was no relationship with age.

引用

页码：411 / 417

页数：7

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