Exosome-mediated peritoneal dissemination in gastric cancer and its clinical applications

被引：22

作者：

Chen, Kai-Bo ^{[1
]}

Chen, Jian ^{[1
]}

Jin, Xiao-Li ^{[1
]}

Huang, Yi ^{[1
]}

Su, Qiu-Ming ^{[1
]}

Chen, Li ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Med, Affiliated Hosp 2, Dept Gen Surg, 88 Jiefang Rd, Hangzhou 310000, Zhejiang, Peoples R China

来源：

BIOMEDICAL REPORTS | 2018年 / 8卷 / 06期

关键词：

exosomes; peritoneal dissemination; gastric cancer; microRNAs;

D O I：

10.3892/br.2018.1088

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The prognosis of patients with peritoneal dissemination from gastric cancer is poor, and the underlying molecular mechanism remains unclear. Exosomes, as macromolecular phospholipid bilayer vesicles comprising of proteins, nucleic acids and lipids, serve as mediators of cell-cell communication. Gastric cancer tumor-derived exosomes may be involved in the pathological process of peritoneal dissemination by mediating crosstalk between cancer cells and mesothelial cells, to result in the induction of enhanced tumor growth, migratory, adhesive and invasive abilities, peritoneal fibrosis and apoptosis, mesothelial-to-mesenchymal transition, angiogenesis and chemoresistance. The present review focuses on previous studies addressing the exosome-dependent molecular transfer in peritoneal dissemination in gastric cancer and the potential clinical applications.

引用

页码：503 / 509

页数：7

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