REGULATION OF SYNAPSE DENSITY BY 5-HT2A RECEPTOR AGONIST AND ANTAGONIST IN THE SPINAL-CORD OF CHICKEN-EMBRYO

被引：36

作者：

NIITSU, Y

HAMADA, S

HAMAGUCHI, K

MIKUNI, M

OKADO, N

机构：

[1] UNIV TSUKUBA,INST BASIC MED SCI,DEPT ANAT,NEUROBIOL LAB,TSUKUBA,IBARAKI 305,JAPAN

[2] GUNMA UNIV,SCH MED,DEPT PSYCHIAT,MAEBASHI,GUMMA 371,JAPAN

来源：

NEUROSCIENCE LETTERS | 1995年 / 195卷 / 03期

关键词：

SYNAPSE; PLASTICITY; SEROTONIN; RECEPTOR; SPINAL CORD;

D O I：

10.1016/0304-3940(95)11805-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Identification of mechanisms that regulate the number of synapses in the brain has been a key issue for understanding the mechanism of plasticity. Here, we report that the density of synapses can be changed using an antagonist and/or an agonist of serotonin (5-HT) type 2A receptors in the chicken spinal cord. Because of the widespread distribution pattern of 5-HT fibers and 5-HT2A receptors in the central nervous system, 5-HT is thought to play a role in the formation and maintenance of synapses that are involved in normal brain function and mechanism of plasticity.

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页码：159 / 162

页数：4

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