ESTIMATION OF BLOOD-GLUCOSE VARIABILITY IN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS

被引:27
|
作者
MOBERG, E
KOLLIND, M
LINS, PE
ADAMSON, U
机构
来源
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1993年 / 53卷 / 05期
关键词
METABOLIC CONTROL; SELF-MONITORING OF BLOOD GLUCOSE; UNSTABLE DIABETES;
D O I
10.3109/00365519309092547
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The aim of the study described here was to evaluate the standard deviation (SD) as a measure of blood-glucose variability in IDDM patients under 'normal life' conditions. One hundred IDDM patients performed self-monitoring of blood glucose (SMBG) five times every 2 days for 4 weeks. From these records the following measurements were calculated for each patient: the standard deviation of all blood-glucose values (SD(BG)), the M-value, the percentage of values < 3 and > 15 mmol l-1 (PE), and the mean, absolute difference of consecutive blood-glucose values (MAD), a novel measure of blood-glucose variability, also taking into consideration the succession of the values. Before the study the patients as well as their physicians were asked to estimate the blood-glucose stability of the patient, using a five-category scale of statements. The patients recorded an average of 64 (range: 32-70) SMBG values. The SD(BG) was normally distributed with a mean of 3.9 +/- 1.0 mmol l-1. There was a highly significant correlation between the SD(BG) and the other measures of blood-glucose variability (p = 0.0001, r > 0.8). It appeared that the variation of the SMBG values recorded before dinner contributed to the total glucose variability to a great extent. There was a poor agreement between the subjective estimations of the blood-glucose stability made by the patients and the physicians and the objective measures of the blood-glucose variability. It is concluded that the SD provides an accurate and easily available estimate of blood-glucose variability in IDDM patients practising home blood-glucose monitoring.
引用
收藏
页码:507 / 514
页数:8
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