THE CONCENTRATION OF ASCORBIC-ACID, OF GLUCOSE AND OF CORTISOL IN THE PLASMA OF SHEEPS AND THE EXCRETION OF ASCORBIC-ACID IN THE URINE AFTER THE INTRAVENOUS-INJECTION OF THE COMPOUND

In lambs, adult female sheeps and wethers the influence of the intravenous injection of ascorbic acid (AA) in a dose of 10, 20 or 30 mg/kg body weight (b.w.) on the concentration of AA in the plasma up to 420 minutes thereafter was analysed. Further the concentration of glucose respectively of cortisol in the plasma was determined in some experiments. The results can be used as a basis for investigations in sheeps with infectious and parasitic diseases for the determination of the degree of the saturation of the body with AA. For therapeutic purposes the repeated application of a dose of 20 mg AA/kg b.w. is recommended. In wethers a dose dependent excretion of AA in the urine after an i.v. injection of a dose of 10, 20 or 30 mg/kg b.w. was observed. The injection of ACTH, cortisol, adrenaline and noradrenaline had no substantial influence on the concentration of AA in the plasma. In the course of 24 hours there was no alteration in the concentration of AA in the plasma.