RECEPTOR-MEDIATED INTERNALIZATION OF FLUORESCENT CHEMOTACTIC PEPTIDE BY HUMAN-NEUTROPHILS

被引：171

作者：

NIEDEL, JE ^{[1
]}

KAHANE, I ^{[1
]}

CUATRECASAS, P ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DURHAM,NC 27710

来源：

SCIENCE | 1979年 / 205卷 / 4413期

关键词：

D O I：

10.1126/science.472759

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Tetramethylrhodamine labeled N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a potent chemoattractant for human neutrophils. Binding of this peptide to living neutrophils was observed by means of video intensification microscopy. At 37°C, diffuse membrane fluorescence was seen initially, followed by rapid aggregation and internalization of the fluorescent peptide. These processes are dependent on specific binding to the formyl peptide chemotactic receptor.

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收藏

页码：1412 / 1414

页数：3

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