RECEPTOR-MEDIATED INTERNALIZATION OF FLUORESCENT CHEMOTACTIC PEPTIDE BY HUMAN-NEUTROPHILS

被引：171
作者：
NIEDEL, JE [1 ]
KAHANE, I [1 ]
CUATRECASAS, P [1 ]
机构：
[1] DUKE UNIV,MED CTR,DURHAM,NC 27710
来源：
SCIENCE | 1979年 / 205卷 / 4413期
关键词：
D O I：
10.1126/science.472759
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Tetramethylrhodamine labeled N-formyl-Nle-Leu-Phe-Nle-Tyr-Lys is a potent chemoattractant for human neutrophils. Binding of this peptide to living neutrophils was observed by means of video intensification microscopy. At 37°C, diffuse membrane fluorescence was seen initially, followed by rapid aggregation and internalization of the fluorescent peptide. These processes are dependent on specific binding to the formyl peptide chemotactic receptor.
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收藏
页码：1412 / 1414
页数：3
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