SPINAL COADMINISTRATION OF PEPTIDE SUBSTANCE-P ANTAGONIST INCREASES ANTINOCICEPTIVE EFFECT OF THE OPIOID PEPTIDE BIPHALIN

被引：43
作者：
MISTEREK, K
MASZCZYNSKA, I
DOROCIAK, A
GUMULKA, SW
CARR, DB
SZYFELBEIN, SK
LIPKOWSKI, AW
机构：
[1] POLISH ACAD SCI, MED RES CTR, PL-00784 WARSAW, POLAND
[2] MED ACAD WARSAW, DEPT PHARMACODYNAM, PL-00927 WARSAW, POLAND
[3] MASSACHUSETTS GEN HOSP, DEPT ANESTHESIA, BOSTON, MA 02114 USA
来源：
LIFE SCIENCES | 1994年 / 54卷 / 14期
关键词：
D O I：
10.1016/0024-3205(94)00494-3
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Intrathecal injection of 0.25 mu g of undecapeptide substance P antagonist (SPA) produced transient antinociception with a peak effect at 5 min. Increasing the SPA dose resulted in neurotoxicity. Intrathecal injection of the opioid peptide biphalin (BIP) produced antinociception for over 3 hrs without neurotoxicity. Coadministration of SPA (at subtoxic doses) increased BIP's antinociceptive effect. Naltrexone reversed analgesia due to BIP alone as well as after BIP+SPA.
引用
收藏
页码：939 / 944
页数：6
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