HEPATITIS-C VIRUS IN MULTIPLE EPISODES OF ACUTE HEPATITIS IN POLYTRANSFUSED THALASSEMIC CHILDREN

被引：249

作者：

LAI, ME

MAZZOLENI, AP

ARGIOLU, F

DEVIRGILIS, S

BALESTRIERI, A

PURCELL, RH

CAO, A

FARCI, P

机构：

[1] UNIV CAGLIARI,INST CLIN & BIOL DEV AGE,CAGLIARI,ITALY

[2] UNIV CAGLIARI,CTR THALASSAEMIA,CAGLIARI,ITALY

[3] NIAID,INFECT DIS LAB,HEPATITIS VIRUSES SECT,BETHESDA,MD 20892

来源：

LANCET | 1994年 / 343卷 / 8894期

关键词：

D O I：

10.1016/S0140-6736(94)91224-6

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the course of distinct episodes of acute non-A, non-B (NANB) hepatitis in three polytransfused thalassaemic children. In each case, the first episode was associated with the appearance of serum hepatitis C virus (HCV) RNA and anti-HCV seroconversion. The second episode was accompanied by the reappearance of HCV viraemia, which in two patients was due to reinfection with a different HCV strain and in the third could be the result of either reactivation of primary infection or reinfection with a new but closely related strain. Thus HCV infection may not induce protective immunity, which has implications for vaccine development.

引用

页码：388 / 390

页数：3

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