MOLECULAR AND CELLULAR BIOLOGY OF OSTEOPONTIN - POTENTIAL ROLE IN CARDIOVASCULAR-DISEASE

被引：119

作者：

GIACHELLI, CM ^{[1
]}

SCHWARTZ, SM ^{[1
]}

LIAW, L ^{[1
]}

机构：

[1] VANDERBILT UNIV, DEPT CELL BIOL, NASHVILLE, TN 37232 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1995年 / 5卷 / 03期

关键词：

D O I：

10.1016/1050-1738(95)00005-T

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Molecular biology has greatly enhanced our ability to identity molecules expressed as a part of the vascular response to injury. Among these, osteopontin is of particular interest. Osteopontin is a multifunctional adhesive glycoprotein implicated in the pathogenesis of a growing number of cardiovascular lesions, including restenosis, atherosclerosis, aortic valve calcification, and repair of myocardial wounds. ln this review, we focus on structural functional and regulatory properties of osteopontin, which might be particularly relevant to cardiovascular lesion development.

引用

页码：88 / 95

页数：8

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