MOLECULAR AND CELLULAR BIOLOGY OF OSTEOPONTIN - POTENTIAL ROLE IN CARDIOVASCULAR-DISEASE

被引：119
作者：
GIACHELLI, CM [1 ]
SCHWARTZ, SM [1 ]
LIAW, L [1 ]
机构：
[1] VANDERBILT UNIV, DEPT CELL BIOL, NASHVILLE, TN 37232 USA
来源：
TRENDS IN CARDIOVASCULAR MEDICINE | 1995年 / 5卷 / 03期
关键词：
D O I：
10.1016/1050-1738(95)00005-T
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Molecular biology has greatly enhanced our ability to identity molecules expressed as a part of the vascular response to injury. Among these, osteopontin is of particular interest. Osteopontin is a multifunctional adhesive glycoprotein implicated in the pathogenesis of a growing number of cardiovascular lesions, including restenosis, atherosclerosis, aortic valve calcification, and repair of myocardial wounds. ln this review, we focus on structural functional and regulatory properties of osteopontin, which might be particularly relevant to cardiovascular lesion development.
引用
收藏
页码：88 / 95
页数：8
相关论文
共 64 条
  • [1] SMOOTH-MUSCLE CELL-MIGRATION AND MATRIX METALLOPROTEINASE EXPRESSION AFTER ARTERIAL INJURY IN THE RAT
    BENDECK, MP
    ZEMPO, N
    CLOWES, AW
    GALARDY, RE
    REIDY, MA
    [J]. CIRCULATION RESEARCH, 1994, 75 (03) : 539 - 545
  • [2] OSTEOPONTIN-HYDROXYAPATITE INTERACTIONS IN-VITRO - INHIBITION OF HYDROXYAPATITE FORMATION AND GROWTH IN A GELATIN-GEL
    BOSKEY, AL
    MARESCA, M
    ULLRICH, W
    DOTY, SB
    BUTLER, WT
    PRINCE, CW
    [J]. BONE AND MINERAL, 1993, 22 (02): : 147 - 159
  • [3] BONE MORPHOGENETIC PROTEIN EXPRESSION IN HUMAN ATHEROSCLEROTIC LESIONS
    BOSTROM, K
    WATSON, KE
    HORN, S
    WORTHAM, C
    HERMAN, IM
    DEMER, LL
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (04) : 1800 - 1809
  • [4] REQUIREMENT OF VASCULAR INTEGRIN ALPHA(V)BETA(3) FOR ANGIOGENESIS
    BROOKS, PC
    CLARK, RAF
    CHERESH, DA
    [J]. SCIENCE, 1994, 264 (5158) : 569 - 571
  • [5] THE NATURE AND SIGNIFICANCE OF OSTEOPONTIN
    BUTLER, WT
    [J]. CONNECTIVE TISSUE RESEARCH, 1989, 23 (2-3) : 123 - 136
  • [6] USE OF A MONOCLONAL-ANTIBODY DIRECTED AGAINST THE PLATELET GLYCOPROTEIN IIB/IIIA RECEPTOR IN HIGH-RISK CORONARY ANGIOPLASTY
    CALIFF, RM
    SHADOFF, N
    VALETT, N
    BATES, E
    GALEANA, A
    KNOPF, W
    SHAFTEL, J
    BENDER, MJ
    AVERSANO, T
    RAQUENO, J
    GURBEL, P
    COWFER, J
    COHEN, M
    CROSS, P
    BITTL, J
    EDDINGS, K
    TAYLOR, M
    DEROSA, K
    HATTEL, L
    COOPER, L
    ESHELMAN, B
    FINTEL, D
    NIEMYSKI, P
    KLEIN, L
    KENNEDY, H
    THORNTON, T
    KEREIAKES, D
    MARTIN, L
    ANDERSON, L
    HIGBY, N
    ELLIS, S
    BREZINA, K
    GEORGE, B
    CHAPEKIS, A
    SMITH, D
    ANWAR, A
    GERBER, TL
    PRITCHARD, GL
    MYLER, R
    SHAW, R
    MURPHY, M
    WARD, K
    MADIGAN, NP
    BLANKENSHIP, J
    HALBERT, M
    FLANAGAN, C
    TANNENBAUM, M
    POLICH, M
    STEVENSON, C
    TCHENG, J
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1994, 330 (14) : 956 - 961
  • [7] CHAMBERS AF, 1993, CANCER RES, V53, P701
  • [8] INHIBITION OF NEOINTIMAL HYPERPLASIA BY BLOCKING ALPHA(V)BETA(3), INTEGRIN WITH A SMALL PEPTIDE ANTAGONIST GPENGRGDSPCA
    CHOI, ET
    ENGEL, L
    CALLOW, AD
    SUN, SP
    TRACHTENBERG, J
    SANTORO, S
    RYAN, US
    [J]. JOURNAL OF VASCULAR SURGERY, 1994, 19 (01) : 125 - 134
  • [9] BETA-1 AND BETA-3 INTEGRINS HAVE DIFFERENT ROLES IN THE ADHESION AND MIGRATION OF VASCULAR SMOOTH-MUSCLE CELLS ON EXTRACELLULAR-MATRIX
    CLYMAN, RI
    MAURAY, F
    KRAMER, RH
    [J]. EXPERIMENTAL CELL RESEARCH, 1992, 200 (02) : 272 - 284
  • [10] SECRETED PHOSPHOPROTEIN MESSENGER-RNA IS INDUCED DURING MULTISTAGE CARCINOGENESIS IN MOUSE SKIN AND CORRELATES WITH THE METASTATIC POTENTIAL OF MURINE FIBROBLASTS
    CRAIG, AM
    BOWDEN, GT
    CHAMBERS, AF
    SPEARMAN, MA
    GREENBERG, AH
    WRIGHT, JA
    MCLEOD, M
    DENHARDT, DT
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1990, 46 (01) : 133 - 137
1234567