REACTIONS OF BETA-(LITHIOMETHYL)AZINES WITH NITRILES AS A ROUTE TO PYRROLOPYRIDINES, PYRROLOQUINOLINES, PYRROLOPYRAZINES, PYRROLOQUINOXALINES AND PYRROLOPYRIMIDINES

被引：53

作者：

DAVIS, ML ^{[1
]}

WAKEFIELD, BJ ^{[1
]}

WARDELL, JA ^{[1
]}

机构：

[1] UNIV SALFORD,DEPT CHEM & APPL CHEM,COCKCROFT BLDG,SALFORD M5 4WT,LANCS,ENGLAND

来源：

TETRAHEDRON | 1992年 / 48卷 / 05期

关键词：

BETA-METHYLAZINES AND DIAZINES; DEPROTONATION; NITRILES; CYCLIZATION; PYRROLOPYRIDINES AND RELATED HETEROCYCLES;

D O I：

10.1016/S0040-4020(01)88196-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Deprotonation of 3-methylpyridine, followed by reaction with benzonilile, gives an intermediate which, on treatment with additional strong base, cyclises to give 2-phenyl[1H]-pyrrolo[2,3-b]pyridine. The application of this type of reaction to a variety of nitriles and beta-methylazines (pyridines, quinolines, pyridines, quinoxalines and pyrimidines) is described.

引用

页码：939 / 952

页数：14

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