MODIFICATION OF D-GALACTOSAMINE-INDUCED LIVER-INJURY IN THE RAT BY SPIRONOLACTONE

被引：1

作者：

MIHAS, AA ^{[1
]}

FOSTER, MM ^{[1
]}

BARNES, S ^{[1
]}

MIHAS, TA ^{[1
]}

HIRSCHOWITZ, BI ^{[1
]}

SPENNEY, JG ^{[1
]}

机构：

[1] VET ADM HOSP, BIRMINGHAM, AL 35233 USA

来源：

PHARMACOLOGY | 1979年 / 18卷 / 05期

关键词：

Bile salts; D-Galactosamine; Hepatic necrosis; Hepatotoxicity; Liver injury; Rat liver; Serum bile salt measurement; Spironolactone;

D O I：

10.1159/000137258

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Spironolactone, a competitive inhibitor of mineralocorticoid effects on the distal tubule of the kidney, has recently been found to have other metabolic effects. In these studies, spironolactone (200 mg/kg intraperitoneally) for 3 days was found to have a marked protective effect against die hepatotoxic effect of D-galactosamine (275 mg/kg) in rats. Further progress in defining the mechanism of protection from D-galactosamine hepatic necrosis by spironolactone will require assessment of effects of spironolactone on uridine nucleotide metabolism. © 1979 S. Karger AG, Basel.

引用

页码：235 / 240

页数：6

共 15 条

[1]

DECKER K, 1972, P183

[2] INTERACTIONS OF SPRIONOLACTONE WITH HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEMS [J].