DIASTEREOSELECTIVE SYNTHESIS OF 2,6-DISUBSTITUTED 3-HYDROXYPIPERIDINE, 2-(ALPHA-HYDROXYALKYL)-3-HYDROXYPIPERIDINE AND 2-(ALPHA-HYDROXYALKYL)-3-HYDROXYPYRROLIDINE DERIVATIVES

被引：10

作者：

KANO, S

YUASA, Y

MOCHIZUKI, N

SHIBUYA, S

机构：

[1] Tokyo College of Pharmacy, Hachioji, Tokyo, 192-03

来源：

HETEROCYCLES | 1990年 / 30卷 / 01期

关键词：

D O I：

10.3987/COM-89-S24

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reduction of 5-substituted 5,8a-trans-oxazolo[3,4-a]pyridin-8-ones (7a,b), obtained by an application of α-acylamino radical cyclization at the initial stage, with NaBH4 and K-Selectride was found to proceed with complete stereocontrol in all cases. Reduction of 1-substituted 1,8a-trans-oxazolo[3,4-a]pyridin-8-one (7c) and pyrrolidine analogue (10) with NaBH4 and K-Selectride was also found to proceed with high diastereoselectivity. © 1990.

引用

页码：263 / 266

页数：4

共 9 条

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