Pathophysiology of nephrogenic systemic fibrosis: A review of experimental data

被引：16

作者：

Morcos, Sameh K. ^{[1
]}

Haylor, John ^{[2
]}

机构：

[1] Sheffield Teaching Hosp NHS Fdn Trust, Dept Diagnost Imaging, Sheffield S5 7AU, S Yorkshire, England

[2] Univ Sheffield, Acad Dept Nephrol, Sheffield S5 7AU, S Yorkshire, England

来源：

WORLD JOURNAL OF RADIOLOGY | 2010年 / 2卷 / 11期

关键词：

Experimental models; Gadolinium-based contrast agents; Nephrogenic systemic fibrosis; Pathophysiology;

D O I：

10.4329/wjr.v2.i11.427

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Since the association between nephrogenic systemic fibrosis (NSF) and gadolinium contrast agents (Gd-CAs) was suggested in 2006, several experimental studies have been published to elucidate the role of these agents in the pathogenesis of NSF. Low stability Gd-CAs have a stimulant effect on human skin and fibroblasts in culture and modulate the production of collagen by these cells. Low stability agents have also induced NSF-like skin changes in a rat model with normal renal function after multiple repeat administrations. The role of the 5/6 subtotal nephrectomy rat model in investigating NSF remains under evaluation. (c) 2010 Baishideng. All rights reserved.

引用

页码：427 / 433

页数：7

共 31 条

[1] SIMS imaging of gadolinium isotopes in tissue from Nephrogenic Systemic Fibrosis patients: Release of free Gd from magnetic resonance imaging (MRI) contrast agents
Abraham, Jerrold L.
Chandra, Subhash
Thakral, Charu
Abraham, Joshua M.
[J]. APPLIED SURFACE SCIENCE, 2008, 255 (04) : 1181 - 1184
[2] Gadolinium deposition in nephrogenic fibrosing dermopathy
Boyd, Alan S.
Zic, John A.
Abraham, Jerrold L.
[J]. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2007, 56 (01) : 27 - 30
[3] THE RELATIONSHIP BETWEEN THERMODYNAMICS AND THE TOXICITY OF GADOLINIUM COMPLEXES
CACHERIS, WP
QUAY, SC
ROCKLAGE, SM
[J]. MAGNETIC RESONANCE IMAGING, 1990, 8 (04) : 467 - 481
[4] Clinical and histological findings in nephrogenic systemic fibrosis
Cowper, Shawn E.
Rabach, Morgan
Girardi, Michael
[J]. EUROPEAN JOURNAL OF RADIOLOGY, 2008, 66 (02) : 191 - 199
[5] DROUVEN BJ, 1986, J BIOL CHEM, V261, P1792
[6] Gadodiamide contrast agent 'activates' fibroblasts: a possible cause of nephrogenic systemic fibrosis
Edward, M.
Quinn, J. A.
Mukherjee, S.
Jensen, M-BV
Jardine, A. G.
Mark, P. B.
Burden, A. D.
[J]. JOURNAL OF PATHOLOGY, 2008, 214 (05) : 584 - 593
[7] Edward M, 2009, C ABSTRACT ECR
[8] THE PROMOTION OF COLLAGEN POLYMERIZATION BY LANTHANIDE AND CALCIUM-IONS
EVANS, CH
DROUVEN, BJ
[J]. BIOCHEMICAL JOURNAL, 1983, 213 (03) : 751 - 758
[9] Stability of Gadolinium-Based Magnetic Resonance Imaging Contrast Agents in Human Serum at 37°C
Frenzel, Thomas
Lengsfeld, Philipp
Schirmer, Heiko
Huetter, Joachim
Weinmann, Hanns-Joachim
[J]. INVESTIGATIVE RADIOLOGY, 2008, 43 (12) : 817 - 828
[10] Effects of Gadolinium Contrast Agents in Naive and Nephrectomized Rats: Relevance to Nephrogenic Systemic Fibrosis
Grant, D.
Johnsen, H.
Juelsrud, A.
Lovhaug, D.
[J]. ACTA RADIOLOGICA, 2009, 50 (02) : 156 - 169

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