DNA LOOP REPAIR BY HUMAN CELL-EXTRACTS

被引：128

作者：

UMAR, A ^{[1
]}

BOYER, JC ^{[1
]}

KUNKEL, TA ^{[1
]}

机构：

[1] NIEHS,MOLEC GENET LAB,RES TRIANGLE PK,NC 27709

来源：

SCIENCE | 1994年 / 266卷 / 5186期

关键词：

D O I：

10.1126/science.7973637

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An activity in human cell extracts is described tt lat repairs DNA with loops of five or more unpaired bases. Repair is strand-specific and is directed by a nick located 5' or 3' to the loop. This repair is observed in a colorectal cancer cell line that is devoid of a wild-type hMLH1 gene and is deficient in repair of mismatches. However, a cell line with deletions in both hMSH2 alleles is deficient in repair of both loops and mismatches. Defects in loop repair may be relevant to the repetitive-sequence instability observed in cancers and other hereditary diseases.

引用

页码：814 / 816

页数：3

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