CD40 LIGAND AND ITS ROLE IN X-LINKED HYPER-IGM SYNDROME

被引：250

作者：

CALLARD, RE ^{[1
]}

ARMITAGE, RJ ^{[1
]}

FANSLOW, WC ^{[1
]}

SPRIGGS, MK ^{[1
]}

机构：

[1] IMMUNEX CORP,SEATTLE,WA 98101

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 11期

关键词：

D O I：

10.1016/0167-5699(93)90188-Q

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CD40 ligand (CD40L) on activated T cells binding to CD40 on B cells is of critical importance for Ig heavy-chain switching and rescue of B cells from apoptosis after somatic mutation in the germinal centre. Mutations in the CD40L gene are now known to cause X-linked hyper-IgM syndrome (HIGM1), an immunodeficiency characterized by the absence of serum IgG, IgA and IgE. In this review, we discuss bow basic and clinical immunology have combined to provide major insights into the function of CD40 in T-B cell collaboration.

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页码：559 / 564

页数：6

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