Atrial fibrillation in patients with diabetes: molecular mechanisms and therapeutic perspectives

被引：44
作者：
De Sensi, Francesco [1 ]
De Potter, Tom [2 ]
Cresti, Alberto [3 ]
Severi, Silva [3 ]
Breithardt, Guenter [4 ]
机构：
[1] Misericordia Hosp, Dept Cardiol, Arrhythmia Unit, Grosseto, Italy
[2] Onze Lieve Vrouw Hosp, Dept Cardiol, Arrhythmia Unit, Aalst, Belgium
[3] Misericordia Hosp, Dept Cardiol, Grosseto, Italy
[4] Univ Hosp, Dept Cardiovasc Med, Munster, Germany
来源：
CARDIOVASCULAR DIAGNOSIS AND THERAPY | 2015年 / 5卷 / 05期
关键词：
Atrial fibrillation (AF); diabetes mellitus (DM); anticoagulants; catheter ablation;
D O I：
10.3978/j.issn.2223-3652.2015.06.03
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Atrial fibrillation (AF) remains the most frequent sustained cardiac arrhythmia worldwide and its incidence increases with ageing, cardiovascular risk factors and comorbidities. Prevalence of diabetes mellitus (DM) is growing fast and is assuming pandemic proportions mostly due to overnutrition and sedentary habits. Experimental and clinical evidences suggest that DM and AF are strongly interconnected. The present review addresses in detail new molecular pathways implicated in the etiology of AF and their relevance for mechanism-based therapeutic strategies in this setting. Advances in risk stratification, drug therapy (i. e., novel anticoagulants) and catheter ablation are also described.
引用
收藏
页码：364 / 373
页数：10
相关论文
共 67 条
[1]   Factors Affecting Quality of Anticoagulation Control Among Patients With Atrial Fibrillation on Warfarin The SAMe-TT2R2 Score [J].
Apostolakis, Stavros ;
Sullivan, Renee M. ;
Olshansky, Brian ;
Lip, Gregory Y. H. .
CHEST, 2013, 144 (05) :1555-1563
[2]  
Arboix Adria, 2009, Expert Rev Cardiovasc Ther, V7, P1181, DOI 10.1586/erc.09.98
[3]   Familial aggregation of atrial fibrillation in Iceland [J].
Arnar, DO ;
Thorvaldsson, S ;
Manolio, TA ;
Thorgeirsson, G ;
Kristjansson, K ;
Hakonarson, H ;
Stefansson, K .
EUROPEAN HEART JOURNAL, 2006, 27 (06) :708-712
[4]   INDEPENDENT RISK-FACTORS FOR ATRIAL-FIBRILLATION IN A POPULATION-BASED COHORT - THE FRAMINGHAM HEART-STUDY [J].
BENJAMIN, EJ ;
LEVY, D ;
VAZIRI, SM ;
DAGOSTINO, RB ;
BELANGER, AJ ;
WOLF, PA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (11) :840-844
[5]   Stroke prevention - Hypertension, diabetes, tobacco, and lipids [J].
Benson, RT ;
Sacco, RL .
NEUROLOGIC CLINICS, 2000, 18 (02) :309-+
[6]   Stroke prevention in atrial fibrillation: Warfarin faces its challengers [J].
Blackshear J.L. ;
Kusumoto F. .
Current Cardiology Reports, 2005, 7 (1) :16-22
[7]   Diabetes, fasting glucose levels, and risk of ischemic stroke and vascular events - Findings from the Northern Manhattan study (NOMAS) [J].
Boden-Albala, Bernadette ;
Cammack, Sam ;
Chong, Ji ;
Wang, Culing ;
Wright, Clinton ;
Rundek, Tatjana ;
Elkind, Mitchell S. V. ;
Paik, Myunghee C. ;
Sacco, Ralph L. .
DIABETES CARE, 2008, 31 (06) :1132-1137
[8]   Diabetic cardiomyopathy, causes and effects [J].
Boudina, Sihem ;
Abel, Evan Dale .
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2010, 11 (01) :31-39
[9]   Role of Late Sodium Channel Current Block in the Management of Atrial Fibrillation [J].
Burashnikov, Alexander ;
Antzelevitch, Charles .
CARDIOVASCULAR DRUGS AND THERAPY, 2013, 27 (01) :79-89
[10]   HRS/EHRA/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: Recommendations for personnel, policy, procedures and follow-up [J].
Calkins, Hugh ;
Brugada, Josep ;
Packer, Douglas L. ;
Cappato, Riccardo ;
Chen, Shih-Ann ;
Crijns, Harry J. G. ;
Damiano, Ralph J., Jr. ;
Davies, D. Wyn ;
Haines, David E. ;
Haissaguerre, Michel ;
Lesaka, Yoshito ;
Jackman, Warren ;
Jais, Pierre ;
Kottkamp, Hans ;
Kuck, Karl Heinz ;
Lindsay, Bruce D. ;
Marchlinski, Francis E. ;
McCarthy, Patrick M. ;
Mont, J. Lluis ;
Morady, Fred ;
Nademanee, Koonlawee ;
Natale, Andrea ;
Pappone, Carlo ;
Prystowsky, Eric ;
Raviele, Antonio ;
Ruskin, Jeremy N. ;
Shemin, Richard J. .
EUROPACE, 2007, 9 (06) :335-379
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