ANTAGONIST FOR ATRIAL-NATRIURETIC-PEPTIDE RECEPTORS AMELIORATES GLOMERULAR HYPERFILTRATION IN DIABETIC RATS

被引：20

作者：

KIKKAWA, R ^{[1
]}

HANEDA, M ^{[1
]}

SAKAMOTO, K ^{[1
]}

KOYA, D ^{[1
]}

SHIKANO, T ^{[1
]}

NAKANISHI, S ^{[1
]}

MATSUDA, Y ^{[1
]}

SHIGETA, Y ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,TOKYO RES LABS,MACHIDA,TOKYO 194,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 193卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1681

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To evaluate the possible contribution of atrial natriuretic peptide (ANP) to the development of glomerular hyperfiltration, we examined the effect of nonpeptide competitive antagonist for biological receptors of ANP, HS-142-1, on glomerular filtration rate (GFR) and renal plasma flow (RPF) in diabetic rats. Increased GFR and RPF in diabetic rats were significantly ameliorated by the injection of HS-142-1, while blood pressure remained unchanged. Urinary cyclic GMP excretion was significantly higher in diabetic rats than in control rats and HS-142-1 decreased urinary cGMP excretion significantly. These results indicate that atrial natriuretic peptide contributes to the development of glomerular hyperfiltration and hyperperfusion in diabetes and HS-142-1 might be useful in the treatment of them. © 1993 Academic Press, Inc.

引用

页码：700 / 705

页数：6

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