The bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) in the calvaria defect of rabbit

被引：2

作者：

Song, Ji-Young ^{[1
]}

Kweon, HaeYong ^{[2
]}

Kwon, Kwang Jun ^{[1
]}

Park, Young-Wook ^{[1
]}

Kim, Seong-Gon ^{[1
]}

机构：

[1] Gangneung Wonju Natl Univ, Coll Dent, Dept Oral & Maxillofacial Surg, Kangnung, South Korea

[2] Natl Acad Agr Sci, RDA, Suwon, South Korea

来源：

JOURNAL OF THE KOREAN ASSOCIATION OF ORAL AND MAXILLOFACIAL SURGEONS | 2010年 / 36卷 / 04期

关键词：

Platelet-rich fibrin (PRF); Silk fibroin; Bone regeneration;

D O I：

10.5125/jkaoms.2010.36.4.250

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Introduction: This study evaluated the bone regenerative effect of silk fibroin mixed with platelet-rich fibrin (PRF) of a bone defect in rabbits. Materials and Methods: Ten New Zealand white rabbits were used for this study and bilateral round shaped defects were formed in the parietal bone (diameter: 8.0 mm). The silk fibroin mixed with PRF was grafted into the right parietal bone (experimental group). The left side (control group) was grafted only PRF. The animals were sacrificed at 4 weeks and 8 weeks. A micro-computerized tomography (mu CT) of each specimen was taken. Subsequently, the specimens were decalcified and stained for histological analysis. Results: The average value of plane film analysis was higher in the experimental group than in the control group at 4 weeks and 8weeks after surgery. However, the difference was not statistically significant.(P>0.05) The tissue mineral density (TMD) in the experimental group at 4 weeks after surgery was significantly higher than the control group.(P<0.05) Conclusion: Silk fibroin can be used as a scaffold of PRF for rabbit calvarial defect repair.

引用

页码：250 / 254

页数：5

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