STRUCTURAL STUDIES ON H-2-ANTAGONISTS - CRYSTAL AND MOLECULAR-STRUCTURE OF N-CYANO-N'-METHYL-N''-(2-[(2-AMINO-5-THIAZOLYL)METHYLTHIO]ETHYL)GUANIDINE AND N-CYANO-3-[(2-GUANIDINO-5-THIAZOLYL)METHYLTHIO]PROPIONAMIDINE

被引：0

作者：

IANELLI, S ^{[1
]}

PELIZZI, G ^{[1
]}

机构：

[1] UNIV PARMA,IST CHIM GEN & INORGAN,10I,CTR STUDIO STRUTTURIST DIFFRATTOMETR,VIALE DELLE SCI,I-43100 PARMA,ITALY

来源：

FARMACO | 1992年 / 47卷 / 05期

关键词：

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The crystal and molecular structures of N-cyano-N'-methyl-N"-{2-[(2-amino-5-thiazolyl) methylthio] ethyl} guanidine and N-cyano-3-[(2-guanidino-5-thiazolyl)methylthio]propianamidine are reported. Both molecules are in an extended conformation. In all two crystals a system of hydrogen bonds links the molecules in a three-dimensional network. A comparison with the structure of cimetidine and famotidine is also included.

引用

页码：607 / 621

页数：15

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