STRUCTURAL STUDIES ON H-2-ANTAGONISTS - CRYSTAL AND MOLECULAR-STRUCTURE OF N-CYANO-N'-METHYL-N''-(2-[(2-AMINO-5-THIAZOLYL)METHYLTHIO]ETHYL)GUANIDINE AND N-CYANO-3-[(2-GUANIDINO-5-THIAZOLYL)METHYLTHIO]PROPIONAMIDINE

被引：0
作者：
IANELLI, S [1 ]
PELIZZI, G [1 ]
机构：
[1] UNIV PARMA,IST CHIM GEN & INORGAN,10I,CTR STUDIO STRUTTURIST DIFFRATTOMETR,VIALE DELLE SCI,I-43100 PARMA,ITALY
来源：
FARMACO | 1992年 / 47卷 / 05期
关键词：
D O I：
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中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The crystal and molecular structures of N-cyano-N'-methyl-N"-{2-[(2-amino-5-thiazolyl) methylthio] ethyl} guanidine and N-cyano-3-[(2-guanidino-5-thiazolyl)methylthio]propianamidine are reported. Both molecules are in an extended conformation. In all two crystals a system of hydrogen bonds links the molecules in a three-dimensional network. A comparison with the structure of cimetidine and famotidine is also included.
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页码：607 / 621
页数：15
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