BARORECEPTOR ACTIVATION REDUCES REACTIVITY TO NOXIOUS-STIMULATION - IMPLICATIONS FOR HYPERTENSION

被引：245

作者：

DWORKIN, BR ^{[1
]}

FILEWICH, RJ ^{[1
]}

MILLER, NE ^{[1
]}

CRAIGMYLE, N ^{[1
]}

PICKERING, TG ^{[1
]}

机构：

[1] CORNELL UNIV, MED CTR,NEW YORK HOSP,CTR CARDIOVASC HYPERTENS, NEW YORK, NY 10021 USA

来源：

SCIENCE | 1979年 / 205卷 / 4412期

关键词：

D O I：

10.1126/science.472749

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The hypothesis was tested that an acute rise of blood pressure may reduce reactivity to noxious stimuli through a baroreceptor-mediated reduction of cerebral arousal. When blood pressure was raised by an infusion of phenylephrine, rats showed less running to terminate or avoid noxious stimuli than during saline infusions. This effect was not seen in rats with denervated baroreceptors. The results suggest that a rise of blood pressure could have motivational consequences significant for human hypertension. Copyright © 1979 AAAS.

引用

页码：1299 / 1301

页数：3

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