INVITRO PERFUSED, NON-ISOLATED SMALL-INTESTINE - ONTOGENY OF TRANSMURAL HYDRAULIC PERMEABILITY

被引：10
作者：
WISSER, J
HORSTER, M
机构：
[1] Physiologisches Institut der Universität München, München 2, D-8000
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 1978年 / 373卷 / 02期
关键词：
hydraulic conductance; in vitro perfused non-isolated ileum; Intestinal transport; maturation of small intestine function;
D O I：
10.1007/BF00584862
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Net fluid-flux and transmural hydrostatic hydraulic conductance (Lp) were measured in the rat ileum during postnatal ontogeny, utilizing a refined in vitro, capillary-perfused (non-isolated) preparation for free-flow studies. Volume absorption at low transmural pressure gradient (1-2 cmH2O) was 0.99±0.22 ml/g wet weight·hr in the mature ileum and 1.55±0.42 ml/g wwt·hr in the differentiating intestine. Hydrostatic hydraulic conductance of the mature ileum was 0.76 μl/cm2·cm H2O·hr, indicating that normal hydrostatic pressure gradients are not important for modulation of intestinal absorption. In contrast, Lp was 3.82 μl/cm2·cmH2O·hr in the differentiating ileum, suggesting a significant contribution of pressure-dependent solvent drag to isotonic solute absorption. © 1978 Springer-Verlag.
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页码：205 / 208
页数：4
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