PNEUMOCOCCAL RESISTANCE TO THE 3RD-GENERATION CEPHALOSPORINS - CLINICAL, LABORATORY AND MOLECULAR ASPECTS

被引：23
作者：
KLUGMAN, KP [1 ]
机构：
[1] SAIMR,JOHANNESBURG,SOUTH AFRICA
来源：
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 1994年 / 4卷 / 01期
关键词：
STREPTOCOCCUS-PNEUMONIAE; CEFOTAXIME; CEFTRIAXONE; 3RD-GENERATION CEPHALOSPORIN;
D O I：
10.1016/0924-8579(94)90063-9
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Widespread use of third-generation cephalosporins appears to have selected cephalosporin-resistant pneumococci associated with the failure of these agents in the management of meningitis. Breakpoints of 0.5 mg/l for intermediate and 2 mg/l for full resistance are proposed for the treatment of pneumococcal meningitis. As no disc tests reliably identify these breakpoints, MIC or E test confirmation of third-generation cephalosporin resistance is recommended for all strains found resistant to a 1 mug oxacillin disk, Resistant strains can be selected in a single transformation event, with PBP 2X gene rearrangements conferring low level resistance and PBP 1A gene rearrangements conferring full resistance.
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页码：63 / 67
页数：5
相关论文
共 29 条
[1]   RECURRENT MENINGITIS FROM A MULTIPLY RESISTANT STREPTOCOCCUS-PNEUMONIAE STRAIN TREATED WITH ERYTHROMYCIN [J].
ALONSO, J ;
GARCIAFUENTES, M .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1991, 10 (03) :256-256
[2]   IMIPENEM-CILASTATIN THERAPY IN A CHILD WITH MENINGITIS CAUSED BY A MULTIPLY RESISTANT PNEUMOCOCCUS [J].
ASENSI, F ;
PEREZTAMARIT, D ;
OTERO, MC ;
GALLEGO, M ;
LLANES, S ;
ABADIA, C ;
CANTO, E .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1989, 8 (12) :895-895
[3]  
BRADLEY JS, 1991, PEDIATR INFECT DIS J, V10, P871
[4]   CEFOTAXIME BREAKPOINT FOR STREPTOCOCCUS-PNEUMONIAE [J].
CANTON, E .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (03) :616-616
[5]  
CHERUBIN CE, 1989, REV INFECT DIS, V11, P526
[6]   A PNEUMOCOCCAL CLINICAL ISOLATE WITH HIGH-LEVEL RESISTANCE TO CEFOTAXIME AND CEFTRIAXONE [J].
FIGUEIREDO, AMS ;
CONNOR, JD ;
SEVERIN, A ;
PATO, MVV ;
TOMASZ, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (04) :886-889
[7]   SCREENING FOR CEPHALOSPORIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE WITH THE KIRBY-BAUER DISK SUSCEPTIBILITY TEST [J].
FRIEDLAND, IR ;
SHELTON, S ;
MCCRACKEN, GH .
JOURNAL OF CLINICAL MICROBIOLOGY, 1993, 31 (06) :1619-1621
[8]   EVALUATION OF ANTIMICROBIAL REGIMENS FOR TREATMENT OF EXPERIMENTAL PENICILLIN-RESISTANT AND CEPHALOSPORIN-RESISTANT PNEUMOCOCCAL MENINGITIS [J].
FRIEDLAND, IR ;
PARIS, M ;
EHRETT, S ;
HICKEY, S ;
OLSEN, K ;
MCCRACKEN, GH .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (08) :1630-1636
[9]   DILEMMAS IN DIAGNOSIS AND MANAGEMENT OF CEPHALOSPORIN-RESISTANT STREPTOCOCCUS-PNEUMONIAE MENINGITIS [J].
FRIEDLAND, IR ;
SHELTON, S ;
PARIS, M ;
RINDERKNECHT, S ;
EHRETT, S ;
KRISHER, K ;
MCCRACKEN, GH .
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1993, 12 (03) :196-200
[10]   FAILURE OF CHLORAMPHENICOL THERAPY IN PENICILLIN-RESISTANT PNEUMOCOCCAL MENINGITIS [J].
FRIEDLAND, IR ;
KLUGMAN, KP .
LANCET, 1992, 339 (8790) :405-408
123