PROPERTIES AND STRUCTURE OF AQUEOUS-SOLUTIONS OF HYDROXYPROPYL-BETA-CYCLODEXTRIN

被引:44
作者
HAUSLER, O
MULLERGOYMANN, CC
机构
[1] TECH UNIV CAROLO WILHELMINA BRAUNSCHWEIG,INST PHARMAZEUT TECHNOL,MENDELSSOHNSTR 1,W-3300 BRAUNSCHWEIG,GERMANY
[2] ROQUETTE GMBH,FRANKFURT,GERMANY
来源
STARCH-STARKE | 1993年 / 45卷 / 05期
关键词
D O I
10.1002/star.19930450508
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Molecules of hydroxypropyl-beta-cyclodextrin (HPBCD) in aqueous solution interact with each other via hydrogen bonds. Especially for concentrations beyond 50% (w/w), a strong increase in viscosity and a considerable decrease of freezable water can be determined. The addition of substances which are able to break the water structure (urea, KSCN) reduces these effects remarkably. The formation of inclusion compounds with urea could not be detected. Endothermic phase transformations confirm the presence of liquid crystalline structures at low temperatures. These liquid crystalline structures are not detectable at room temperature, but the freeze fracture technique shows micelle-like associates of a size of about 20 nm. Studies on the complexation of phenolphthalein as well as surface tension measurements of HPBCD solutions indicate that a minimum concentration of HPBC is necessary for the association phenomena.
引用
收藏
页码:183 / 187
页数:5
相关论文
共 25 条
  • [1] ALBERS E, 1991, THESIS U KIEL, P44
  • [2] BATZDORF T, IN PRESS PHARM IND
  • [3] BATZDORF T, 1992, EUR J PHARM BIOPHARM, V38, pS13
  • [4] BEYRICH T, 1990, PHARMAZIE, V45, P217
  • [5] BRAUNS U, 1986, THESIS U KIEL
  • [6] AGGREGATION OF CYCLODEXTRINS - AN EXPLANATION OF THE ABNORMAL SOLUBILITY OF BETA-CYCLODEXTRIN
    COLEMAN, AW
    NICOLIS, I
    KELLER, N
    DALBIEZ, JP
    [J]. JOURNAL OF INCLUSION PHENOMENA AND MOLECULAR RECOGNITION IN CHEMISTRY, 1992, 13 (02): : 139 - 143
  • [7] Cserhati T., 1985, TENSIDE DETERGENTS, V22, P237
  • [8] THE EFFECTS OF CYCLODEXTRINS ON DRUG ABSORPTION .2. INVIVO OBSERVATIONS
    FRIJLINK, HW
    EISSENS, AC
    SCHOONEN, AJM
    LERK, CF
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1990, 64 (2-3) : 195 - 205
  • [9] HUTTENRAUCH R, 1982, PHARMAZIE, V37, P720
  • [10] HUTTENRAUCH R, 1985, PHARMAZIE, V40, P199