INVITRO ANTIBACTERIAL ACTIVITY OF BICOZAMYCIN AGAINST PASTEURELLA-PISCICIDA

In vitro antimicrobial activity of bicozamycin (BCM), a cell wall synthesis inhibitor, was investigated against Pasteurella piscicida. Minimum inhibitory concentrations (MIC) of BCM against 263 clinical isolates of P. piscicida ranged from 1.56 to 6.25-mu-g/ml. High incidence of drug-resistant strains against other drugs such as beta-lactam antibiotics and pyridonecarboxylic acids were recognized. No cross resistance between BCM and other antibacterial agents were observed. BCM displayed bactericidal activity at its MIC level. P. piscicida strains showed a slowly increasing and stepwise pattern of artificial development of resistance against BCM. From the results obtained, it may be suggested that BCM would be applied as a new type of therapeutic agent among the cell wall synthesis inhibitors for the treatment of pseudotuberculosis.