Tyrosine Hydroxylase Maps to the Short Arm of Chromosome 11 Proximal to the Insulin and HRAS1 Loci

被引：19

作者：

Xue, F. ^{[1
]}

Kidd, J. R. ^{[1
]}

Pakstis, A. J. ^{[1
]}

Castiglione, C. M. ^{[1
]}

Mallet, J. ^{[2
]}

Kidd, K. K. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Human Genet, New Haven, CT 06510 USA

[2] CNRS, Neurobiol Cellulaire & Mol Lab, F-91190 Gif Sur Yvette, France

来源：

GENOMICS | 1988年 / 2卷 / 04期

关键词：

D O I：

10.1016/0888-7543(88)90016-X

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Tyrosine hydroxylase (TH) is the rate-limiting enzyme for catecholamine biosynthesis and a candidate gene for manic-depressive illness. The TH locus was typed for a BglII RFLP using a cDNA clone Ty7 in four large kindreds. Pairwise analyses and multipoint analyses were carried out to map the TH locus more precisely in the region of the linked markers: D11S12, INS, and HRAS1 on 11p. Results confirm the close linkage between TH with these previously mapped markers and support a most likely ordering which places TH on the side of INS where the centromere lies. (C) 1988 Academic Press, Inc.

引用

页码：288 / 293

页数：6

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