Vagal Nerve Stimulation: Is It Effective in Children with Dravet Syndrome?

被引：5

作者：

Sirsi, Deepa ^{[1
]}

Khan, Muna ^{[1
]}

Arnold, Susan T. ^{[1
]}

机构：

[1] Univ Texas Southwestern Med Ctr Dallas, Div Pediat Neurol, Dallas, TX 75390 USA

来源：

JOURNAL OF PEDIATRIC EPILEPSY | 2016年 / 5卷 / 01期

关键词：

Dravet syndrome; vagal nerve stimulation; intractable epilepsy;

D O I：

10.1055/s-0035-1567851

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Treatment of Dravet syndrome with anti-seizure medications is challenging and frequently disappointing in early childhood. Nonpharmacologic treatments for epilepsy including ketogenic diet, corpus callosotomy, and vagal nerve stimulation (VNS) are considered and used for management of medically refractory epilepsy. In this series, we report our experience with VNS in eight children with Dravet syndrome. Mean age at VNS implantation was 6.2 years. Duration of treatment with VNS ranged from 2 to 13 years. When compared with baseline, four of eight children had a 50 to 75% reduction in seizure frequency or duration. Four children had no significant improvement in seizures after VNS. The device was well tolerated in all patients without significant complications.

引用

页码：7 / 10

页数：4

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