THE MURINE MONOCLONAL-ANTIBODY, 14A2.H1, IDENTIFIES A NOVEL PLATELET SURFACE-ANTIGEN

被引：31

作者：

ASHMAN, LK ^{[1
]}

AYLETT, GW ^{[1
]}

MEHRABANI, PA ^{[1
]}

BENDALL, LJ ^{[1
]}

NIUTTA, S ^{[1
]}

CAMBARERI, AC ^{[1
]}

COLE, SR ^{[1
]}

BERNDT, MC ^{[1
]}

机构：

[1] WESTMEAD HOSP,DEPT MED,WESTMEAD,NSW,AUSTRALIA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1991年 / 79卷 / 02期

关键词：

D O I：

10.1111/j.1365-2141.1991.tb04531.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A murine monoclonal antibody 14A2.H1, raised against acute myeloid leukaemia cells, identifies a previously undescribed 27 kDa platelet surface glycoprotein which is expressed at low copy number (10(3)/platelet). MAb 14A2.H1 caused aggregation of platelets which was dependent on Fc-gamma-RII. Binding of the antibody to platelets was not altered by activation by thrombin or phorbol ester. In haemopoietic cell populations the antibody bound to megakaryocytes, monocytes (weakly), several myeloid leukaemic cell lines and fresh myeloid leukaemic blasts from some patients. Lymphocytes, lymphoid cell lines, neutrophils and haemopoietic progenitor cells were negative. Expression of the antigen was not restricted to haemopoietic cells as epithelial cells in tonsillar crypts and endothelial cells were positive.

引用

页码：263 / 270

页数：8

共 36 条

[1] EXPRESSION OF THE NON-T ALL-ASSOCIATED P24 ANTIGEN ON LEUKEMIC BLASTS FROM PATIENTS WITH ANLL [J].