DIRECT MEASUREMENT OF PLATELET SECRETION IN WHOLE-BLOOD

被引：63

作者：

INGERMAN, CM ^{[1
]}

SMITH, JB ^{[1
]}

SILVER, MJ ^{[1
]}

机构：

[1] THOMAS JEFFERSON UNIV,DEPT PHARMACOL,PHILADELPHIA,PA 19107

来源：

THROMBOSIS RESEARCH | 1979年 / 16卷 / 3-4期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0049-3848(79)90081-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Platelet secretion is usually measured using platelet-rich plasma (PRP) or washed platelets resuspended in buffered saline. We report here measurements of the release of adenosine triphosphate (ATP) from platelets in citrated whole blood in response to thrombin and collagen. The amount of ATP released correlates with the platelet content of the whole blood and is partially dependent on prostaglandin synthesis when release is induced by collagen. Further, the release of ATP does not occur in blood from a patient with storage-pool deficient platelets. © 1979.

引用

页码：335 / 344

页数：10

共 10 条

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[2]

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[3]

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[8]

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[9] PLATELET-AGGREGATION AND RELEASE - EFFECTS OF LOW CONCENTRATIONS OF THROMBIN OR COLLAGEN [J].

PACKHAM, MA ;

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AMERICAN JOURNAL OF PHYSIOLOGY, 1973, 225 (01) :38-47

[10] PERSISTENCE OF THROMBOXANE A2-LIKE MATERIAL AND PLATELET RELEASE-INDUCING ACTIVITY IN PLASMA [J].

SMITH, JB ;

INGERMAN, C ;

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JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (05) :1119-1122

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