CHRONIC ESTROGEN EXPOSURE MAINTAINS ELEVATED LEVELS OF PROGESTERONE-RECEPTOR MESSENGER-RNA IN GUINEA-PIG HYPOTHALAMUS

被引：18
|
作者：
BAYLISS, DA
MILLHORN, DE
机构：
[1] UNIV N CAROLINA,DEPT PHYSIOL,78 MED SCI RES WING,CHAPEL HILL,NC 27599
[2] UNIV N CAROLINA,CURRICULUM NEUROBIOL,CHAPEL HILL,NC 27599
来源：
MOLECULAR BRAIN RESEARCH | 1991年 / 10卷 / 02期
关键词：
INSITU HYBRIDIZATION; PROGESTERONE RECEPTOR; ESTROGEN; GUINEA PIG; HYPOTHALAMUS; STEROID;
D O I：
10.1016/0169-328X(91)90107-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We performed in situ hybridization on hypothalamic sections from ovariectomized guinea pig using a cocktail of three S-35-labeled oligonucleotides complementary to mammalian progesterone receptor (PR) cDNA. PR mRNA was readily detected in hypothalamic neurons from guinea pigs pretreated with 17-beta-estradiol benzoate (E2B), but not from animals which did not receive supplemental E2B. The distribution of PR mRNA-containing cells corresponded well with previous localizations of PR in guinea pig. In contrast to earlier reports of E2B regulation of PR mRNA in rat hypothalamus, however, we found that PR mRNA remained elevated during chronic exposure to E2B (up to 10 days) in guinea pig.
引用
收藏
页码：167 / 172
页数：6
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