Mast cell stabilizing and anti-anaphylactic activity of aqueous extract of green tea (Camellia sinensis)

被引：10

作者：

Balaji, G. ^{[1
]}

Chalamaiah, M. ^{[2
]}

Hanumanna, P. ^{[3
]}

Vamsikrishna, B. ^{[4
]}

Kumar, D. Jagadeesh ^{[5
]}

Babu, V. Venu ^{[2
]}

机构：

[1] Sri Krishnadevaraya Univ, Dept Pharmacol, Anantapur 515003, Andhra Pradesh, India

[2] Natl Inst Nutr, Food & Drug Toxicol Res Ctr, Hyderabad 500604, Andhra Pradesh, India

[3] Nirmala Coll Pharm, Dept Pharmacol, Kadapa, AP, India

[4] Hetero Labs Ltd, Dept Res & Dev, Unit 3, Hyderabad, Andhra Pradesh, India

[5] Sri Krishnadevaraya Univ, Dept Pharmaceut, Anantapur 515003, Andhra Pradesh, India

来源：

INTERNATIONAL JOURNAL OF VETERINARY SCIENCE AND MEDICINE | 2014年 / 2卷 / 01期

关键词：

Green tea extract; Mast cell stabilization; Anti-anaphylactic activity; Compound; 48/80; IR and UV-Visible spectroscopy;

D O I：

10.1016/j.ijvsm.2014.03.001

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Green tea (Camellia sinensis) is one of the most popular and widely consumed beverages in the world. In the current study, aqueous extract of green tea (C. sinensis) was evaluated for mast cell stabilizing and anti-anaphylactic activities. Green tea extract (11, 13, 15 mg/ml) significantly (P < 0.05) inhibited compound 48/80-induced rat mesentric mast cell degranulation in a dose dependent manner. Anti-anaphylactic activity of green tea extract was performed in female mice. At a dose of 400, 500, 600 mg/kg BW, green tea extract showed significant reduction in the mortality of mice subjected to anaphylactic shock by compound C-48/80. Ketotifen was used for comparison. In addition, IR and UV-Visible spectroscopy analysis of green tea extract revealed the presence of functional groups of bioactive compounds. These results suggest that green tea could be useful in the treatment of asthma and allergic rhinitis. (C) 2014 Production and hosting by Elsevier B.V. on behalf of Faculty of Veterinary Medicine, Cairo University.

引用

页码：89 / 94

页数：6

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