Early Prenatal Detection of Mutation of Dystrophin Gene in Patients With Duchenne Muscular Dystrophy

As far as at this current stage in practical healthcare there is actual problem we have necessity to search for new ways of early detection of hereditary diseases and identification of precise mutation borders. An article is considered the multiplex ligation-dependent probe amplification (MLPA) making it possible to expand the search for mutation boundaries and predict the probability of birth of an unhealthy child which was developed according to our research. The developed method of pre-clinical diagnostics for predicting mutations in the dystrophin gene in its heterozygous state in pre- and postnatal periods is allowed to identify "hot spots" of break between exons 45-50 of DMD gene.