IMMUNOTHERAPY OF SOLID TUMOR BY INTRATUMORAL INFUSION OF LYMPHOKINE-ACTIVATED KILLER CELLS

被引：4

作者：

YAMAKI, T ^{[1
]}

IBAYASHI, Y ^{[1
]}

NAKAMURA, T ^{[1
]}

SHIJUBO, N ^{[1
]}

DAIBO, M ^{[1
]}

KAWAHARA, T ^{[1
]}

HASHI, K ^{[1
]}

机构：

[1] SAPPORO MED COLL, DEPT PATHOL, SAPPORO, HOKKAIDO 060, JAPAN

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1988年 / 79卷 / 08期

关键词：

D O I：

10.1111/j.1349-7006.1988.tb00053.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Fifty million lymphokine-activated killer (LAK) cells were infused into rat T9 gliosarcoma tumors for 1 hr at an infusion rate of 0.1 ml/hr. Cultured normal spleen cells were infused into similar tumors as a control. The LAK cell-treated tumors began to regress to approximately 3 weeks after infusion and disappeared by 6 weeks, while the cultured normal spleen cell-treated tumors grew progressively. Immunohistochemical analysis demonstrated prominent infiltration of cytotoxic/suppressor T cells in the LAK cell-treated tumors, while few lymphocytes were recognized in the control tumors. These data suggested that LAK cells infused intratumorally might be capable of mediating tumor regression by inducing host immunity against the tumor.

引用

页码：903 / 908

页数：6

共 27 条

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