RESTRAINT STRESS SUPPRESSES EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN LEWIS RATS

被引：40

作者：

KURODA, Y ^{[1
]}

MORI, T ^{[1
]}

HORI, T ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC MED,DEPT PHYSIOL,FUKUOKA 812,JAPAN

来源：

BRAIN RESEARCH BULLETIN | 1994年 / 34卷 / 01期

关键词：

RESTRAINT STRESS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MULTIPLE SCLEROSIS;

D O I：

10.1016/0361-9230(94)90180-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effect of restraint stress on experimental allergic encephalomyelitis (EAE), a model for the human disease multiple sclerosis (MS), in Lewis rats. Rats were subjected to 12 h restraint stress for 3 consecutive nights from the first (day 1) or the eighth day (day 8) after sensitization with the antigen (guinea-pig spinal cord). All controlled rats exhibited clinical and histologic signs of EAE. The mean +/- SD of incubation time, clinical score (0-4) and histologic score (0-3) for this group were 12.8 +/- 1.0 days, 2.7 +/- 0.6, and 2.3 +/- 0.7, respectively. Restraint stress from day 8 significantly suppressed EAE: the mean +/- SD of incubation time, clinical score, and histologic score for this group were 17.2 +/- 2.2 days (p < 0.001), 1.8 +/- 1.3 (p < 0.05), and 1.5 +/- 0.9 (p < 0.02), respectively. Restraint stress from day 1 did not modify EAE. The findings suggest that stressful factors may exert an influence on the clinical course of MS.

引用

页码：15 / 17

页数：3

共 24 条

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