NEOPTERIN MEASUREMENT PROVIDES EVIDENCE OF ALTERED CELL-MEDIATED-IMMUNITY IN PATIENTS WITH DEPRESSION, BUT NOT WITH SCHIZOPHRENIA

被引：74

作者：

DUNBAR, PR ^{[1
]}

HILL, J ^{[1
]}

NEALE, TJ ^{[1
]}

MELLSOP, GW ^{[1
]}

机构：

[1] WELLINGTON SCH MED, DEPT PSYCHOL MED, WELLINGTON, NEW ZEALAND

来源：

PSYCHOLOGICAL MEDICINE | 1992年 / 22卷 / 04期

关键词：

D O I：

10.1017/S0033291700038629

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Neopterin is a validated marker of the activation of cell-mediated immunity in a variety of disease states. We measured neopterin and creatinine concentrations in the plasma and urine of 22 schizophrenic and 26 depressed patients admitted acutely to hospital, and compared results with those in a large group of normal controls. Neopterin/creatinine ratios were normal in the schizophrenic patients, but significantly elevated in the plasma of depressed patients. In each diagnostic group, the use of psychotropic drugs before admission had no effect on the neopterin ratios observed. Our findings indicate altered cell-mediated immunity in depression.

引用

页码：1051 / 1057

页数：7