LINKAGE MAPPING OF HIGHLY INFORMATIVE DNA POLYMORPHISMS WITHIN THE HUMAN INTERFERON-ALPHA RECEPTOR GENE ON CHROMOSOME-21

被引：35
作者：
MCINNIS, MG
LUTFALLA, G
SLAUGENHAUPT, S
PETERSEN, MB
UZE, G
CHAKRAVARTI, A
ANTONARAKIS, SE
机构：
[1] JOHNS HOPKINS UNIV,SCH MED,CTR MED GENET,BALTIMORE,MD 21205
[2] JOHNS HOPKINS UNIV,SCH MED,DEPT PEDIAT,BALTIMORE,MD 21205
[3] JOHNS HOPKINS UNIV,SCH MED,DEPT PSYCHIAT,BALTIMORE,MD 21205
[4] CNRS,VIRAL ONCOL LAB,F-94800 VILLEJUIF,FRANCE
[5] UNIV PITTSBURGH,DEPT PSYCHIAT,PITTSBURGH,PA 15261
[6] UNIV PITTSBURGH,DEPT HUMAN GENET,PITTSBURGH,PA 15261
来源：
GENOMICS | 1991年 / 11卷 / 03期
关键词：
D O I：
10.1016/0888-7543(91)90064-L
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Two polymorphic loci within the interferon-α receptor (IFNAR) gene on human chromosome 21 have been identified and mapped by linkage analysis in 40 CEPH families. These markers are (1) a multiallelic RFLP with an observed heterozygosity of 0.72 and (2) a variable (AT3)n short sequence repeat at the poly(A) tail of an Alu sequence (AluVpA) with an observed heterozygosity of 0.83. This locus is close to D21S58 (θ̂ = 0.02, Z ̂ = 36.76) and D21S17 (θ̂ = 0.02, Z ̂ = 21.76) within chromosomal band 21q22.1. Multipoint linkage analysis suggests the most likely locus order to be 21cen-D21S58-IFNAR-D21S17-21qter. Given its high heterozygosity, the IFNAR gene can be used as an index marker on human chromosome 21. © 1991.
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页码：573 / 576
页数：4
相关论文
共 21 条
[1]   PROGRAM DESCRIPTION - CENTER-DETUDE-DU-POLYMORPHISME-HUMAIN (CEPH) - COLLABORATIVE GENETIC-MAPPING OF THE HUMAN GENOME [J].
DAUSSET, J ;
CANN, H ;
COHEN, D ;
LATHROP, M ;
LALOUEL, JM ;
WHITE, R .
GENOMICS, 1990, 6 (03) :575-577
[2]   THE POLYDEOXYADENYLATE TRACT OF ALU REPETITIVE ELEMENTS IS POLYMORPHIC IN THE HUMAN GENOME [J].
ECONOMOU, EP ;
BERGEN, AW ;
WARREN, AC ;
ANTONARAKIS, SE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :2951-2954
[3]   ANTITUMOR EFFECTS OF INTERFERON [J].
GRESSER, I .
ACTA ONCOLOGICA, 1989, 28 (03) :347-353
[4]   HYPERVARIABLE MINISATELLITE REGIONS IN HUMAN DNA [J].
JEFFREYS, AJ ;
WILSON, V ;
THEIN, SL .
NATURE, 1985, 314 (6006) :67-73
[5]  
KORENBERG JR, 1990, AM J HUM GENET, V47, P236
[6]   SUBLOCALIZATION ON CHROMOSOME-21 OF HUMAN INTERFERON-ALPHA RECEPTOR GENE AND THE GENE FOR AN INTERFERON-GAMMA RESPONSE PROTEIN [J].
LANGER, JA ;
RASHIDBAIGI, A ;
LAI, LW ;
PATTERSON, D ;
JONES, C .
SOMATIC CELL AND MOLECULAR GENETICS, 1990, 16 (03) :231-240
[7]  
LATHROP GM, 1988, AM J HUM GENET, V42, P498
[8]  
LITT M, 1989, AM J HUM GENET, V44, P397
[9]   ASSIGNMENT OF THE HUMAN INTERFERON-ALPHA RECEPTOR GENE TO CHROMOSOME 21Q22.1 BY INSITU HYBRIDIZATION [J].
LUTFALLA, G ;
ROECKEL, N ;
MOGENSEN, KE ;
MATTEI, MG ;
UZE, G .
JOURNAL OF INTERFERON RESEARCH, 1990, 10 (05) :515-517
[10]   MOLECULAR GENETIC APPROACH TO THE CHARACTERIZATION OF THE DOWN SYNDROME REGION OF CHROMOSOME-21 [J].
MCCORMICK, MK ;
SCHINZEL, A ;
PETERSEN, MB ;
STETTEN, G ;
DRISCOLL, DJ ;
CANTU, ES ;
TRANEBJAERG, L ;
MIKKELSEN, M ;
WATKINS, PC ;
ANTONARAKIS, SE .
GENOMICS, 1989, 5 (02) :325-331
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