Targeting of Tumor Necrosis Factor Alpha Receptors as a Therapeutic Strategy for Neurodegenerative Disorders

被引：40

作者：

Dong, Yun ^{[1
]}

Dekens, Doortje W. ^{[1
,2
,3
]}

De Deyn, Peter Paul ^{[2
,3
,4
,5
,6
]}

Naude, Petrus J. W. ^{[1
,2
,3
]}

Eisel, Ulrich L. M. ^{[1
,7
,8
]}

机构：

[1] Univ Groningen, Fac Math & Nat Sci, Dept Mol Neurobiol, NL-9747 AG Groningen, Netherlands

[2] Univ Groningen, Univ Med Ctr Groningen, Dept Neurol, NL-9713 GZ Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Alzheimer Res Ctr, NL-9713 GZ Groningen, Netherlands

[4] Hosp Network Antwerp ZNA, Dept Neurol, B-2020 Antwerp, Belgium

[5] Hosp Network Antwerp ZNA, Memory Clin, B-2020 Antwerp, Belgium

[6] Univ Antwerp, Lab Neurochem & Behav, Biobank, Inst Born Bunge, B-2610 Antwerp, Belgium

[7] Univ Groningen, Univ Med Ctr Groningen, Univ Ctr Psychiat, NL-9713 GZ Groningen, Netherlands

[8] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol Emot Regulat, NL-9713 GZ Groningen, Netherlands

来源：

ANTIBODIES | 2015年 / 4卷 / 04期

关键词：

tumor necrosis factor alpha (TNF-alpha); TNFR1; TNFR2; TNFR signaling pathways; neurodegenerative disorders; therapy;

D O I：

10.3390/antib4040369

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Numerous studies have revealed the pleiotropic functions of tumor necrosis factor alpha (TNF-), and have linked it with several neurodegenerative disorders. This review describes the signaling pathways induced by TNF- via its two receptors (TNFR1 and TNFR2), and their functions in neurodegenerative processes as in Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and ischemic stroke. It has become clear that TNF- may exert divergent actions in neurodegenerative disorders, including neurodegenerative and neuroprotective effects, which appear to depend on its signaling via either TNFR1 or TNFR2. Specific targeting of these receptors is a promising therapeutic strategy for many disorders.

引用

页码：369 / 408

页数：40

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