DIFFERENTIATION OF THE MUMPS VACCINE STRAINS FROM THE WILD VIRUSES BY THE NUCLEOTIDE-SEQUENCES OF THE P-GENE

被引：32

作者：

YAMADA, A ^{[1
]}

TAKEUCHI, K ^{[1
]}

TANABAYASHI, K ^{[1
]}

HISHIYAMA, M ^{[1
]}

TAKAHASHI, Y ^{[1
]}

SUGIURA, A ^{[1
]}

机构：

[1] OSAKA UNIV,RES FDN MICROBIAL DIS,KANONJI INST,KANONJI,KAGAWA 768,JAPAN

来源：

VACCINE | 1990年 / 8卷 / 06期

关键词：

differentiation; Mumps; nucleotide sequence; strains;

D O I：

10.1016/0264-410X(90)90007-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nucleotide sequence analysis of a part of the P gene of mumps virus allowed the differentiation of live attenuated mumps vaccine strains from each other and from wild mumps viruses. Restriction enzyme analysis was found to serve as a convenient method of screening for one strain of mumps vaccine. Examination by the method of virus isolates obtained from the patients who developed mumps parotitis or meningitis following vaccination revealed that most of those viruses were related to the respective vaccine viruses used for immunization. © 1990.

引用

页码：553 / 557

页数：5

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