EFFECTS OF METHAMPHETAMINE ON REGIONAL CEREBRAL GLUCOSE-UTILIZATION IN RATS WITH UNILATERAL LESION OF SUBSTANTIA-NIGRA

被引：2
|
作者：
GOMITA, Y [1 ]
ICHIMARU, Y [1 ]
FURUNO, K [1 ]
ARAKI, Y [1 ]
机构：
[1] DAIICHI COLL PHARMACEUT SCI,DEPT PHARMACOL,FUKUOKA 815,JAPAN
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1990年 / 53卷 / 03期
关键词：
D O I：
10.1254/jjp.53.414
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In rats with electrocoagulation of the unilateral subtantia nigra (SN), methamphetamine at doses of 2.5 and 5 mg/kg, i.p., induced ipsilateral turning towards the lesioned side and caused an imbalance of the regional cerebral glucose utilization (CGU) in the caudate-putamen (CP), frontal cortex (FC) and ventromedial thalamic nucleus (VMT); i.e., showing a higher contralateral CGU as compared with the SN lesioned side. These results induced in unilateral SN-lesioned rats may be accompanied by an imbalance of neural activity in CP, FC and VMT of these rats. © 1990, The Japanese Pharmacological Society. All rights reserved.
引用
收藏
页码：414 / 418
页数：5
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