MECHANISM OF INHIBITION OF RIBOSOMES BY STREPTOMYCIN

被引：48
作者：
MODOLELL, J
DAVIS, BD
机构：
[1] Bacterial Physiology Unit, Harvard Medical School, Boston
来源：
NATURE | 1969年 / 224卷 / 5217期
关键词：
D O I：
10.1038/224345a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
During streptomycin inhibition of translation of phage mRNA the peptidyl-tRNA is blocked in the ribosome P site. The binding of both aminoacyl-tRNA and peptidyl-tRNA to the ribosomal A site is impaired. © 1969 Nature Publishing Group.
引用
收藏
页码：345 / +
页数：1
相关论文
共 27 条
[1]   EFFECT OF SPECTINOMYCIN ON POLPEPTIDE SYNTHESIS IN EXTRACTS OF ESCHERICHIA COLI [J].
ANDERSON, P ;
DAVIES, J ;
DAVIS, BD .
JOURNAL OF MOLECULAR BIOLOGY, 1967, 29 (01) :203-&
[2]   ROLE OF RIBOSOMES IN STREPTOMYCIN-ACTIVATED SUPPRESSION [J].
ANDERSON, WF ;
GORINI, L ;
BRECKENRIDGE, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 54 (04) :1076-+
[3]   CELL-FREE PROTEIN SYNTHESIS PROGRAMMED WITH R17 RNA - INDENTIFICATION OF 2 PHAGE PROTEINS [J].
CAPECCHI, MR .
JOURNAL OF MOLECULAR BIOLOGY, 1966, 21 (01) :173-&
[4]   STREPTOMYCIN ACTION + RIBOSOME [J].
COX, EC ;
FLAKS, JG ;
WHITE, JR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (04) :703-&
[5]   ENZYMATIC HYDROLYSIS OF N-SUBSTITUTED AMINOACYL-TRNA [J].
CUZIN, F ;
KRETCHMER, N ;
GREENBERG, RE ;
HURWITZ, R ;
CHAPEVILLE, F .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1967, 58 (05) :2079-+
[6]   STREPTOMYCIN SUPPRESSION + CODE [J].
DAVIES, J ;
GILBERT, W ;
GORINI, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (05) :883-+
[7]  
DAVIES J, 1965, MOL PHARMACOL, V1, P93
[8]   STUDIES ON RIBOSOMES OF STREPTOMYCIN-SENSITIVE + RESISTANT STRAINS OF ESCHERICHIA COLI [J].
DAVIES, JE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (04) :659-&
[9]   ENZYMATIC HYDROLYSIS OF PEPTIDYL-TRNA [J].
DEGROOT, N ;
PANET, A ;
LAPIDOT, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1968, 31 (01) :37-&
[10]   SUPPRESSION OF MUTATIONS IN ALKALINE PHOSPHATASE STRUCTURAL CISTRON OF E COLI [J].
GAREN, A ;
SIDDIQI, O .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1962, 48 (07) :1121-&
123