STUDY OF THE ACID-BASE BEHAVIOR AND COPPER(II) COMPLEXING PROPERTIES OF URACIL-DERIVED AND HYPOXANTHINE-DERIVED NUCLEOTIDES IN AQUEOUS-SOLUTION

被引：22

作者：

CASASSAS, E ^{[1
]}

GARGALLO, R ^{[1
]}

GIMENEZ, I ^{[1
]}

IZQUIERDORIDORSA, A ^{[1
]}

TAULER, R ^{[1
]}

机构：

[1] UNIV BARCELONA,DEPT ANALYT CHEM,E-08028 BARCELONA,SPAIN

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1994年 / 56卷 / 03期

关键词：

D O I：

10.1016/0162-0134(94)85005-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A comparative study of the acid-base properties and the complex-forming properties with copper(II) ions of the nucleotide uridine-5'-monophosphate (UMP) and the cyclic nucleotides uridine-3',5'-cyclic-monophosphate (cUMP) and inosine-3',5'-cyclic-monophosphate (cIMP) has been carried out. This study was performed from emf and spectrophotometric data in aqueous solution at 37 degrees C and 0.15 M ionic strength, adjusted either with NaNO3 or with NaCl. The pertinent equilibrium constants were determined. The results show that purine derivatives are slightly more acidic than the pyrimidine ones, and that nucleotides and cyclic nucleotides coordinate with metal ions through different main coordination sites.

引用

页码：187 / 199

页数：13

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