Sperm Quality of Male Balb/C Mice after Kepel (Stelechocarpus burahol) Fruit Extract Administration

Kepel (Stelechocarpus burahol) fruits contains phytoestrogen that have been shown to have a potential phytoestrogen that may affect sperm quality. However, few studies on this effect have been conducted. The aim of this study was to evaluate the effect Stelechocarpus burahol administration on sperm quality in mice. This experimental study used post-test only with control-group design. The sox-chlelation method was performed to obtain the ethanol extract from kepel fruit. Twenty four mice were randomly divided into 4 groups of Repel fruit extract dose: 0 mg/mice (control or group I), 0.65 mg/mice (group II), 1.3 mg/mice (group III), and 2.6 mg/ mice (group IV). One milliliter of Repel fruit extract was administered orally every day for 14 days. On day 15 the sperm were collected and analyzed for motility, concentration, viability, and morphology. There was no effect of kepel fruit extract found among the treated groups (group I, II, III, IV) on the percentage of sperm concentration, morphology, and viability (p>0.05). However, the percentage of motility in group IV (kepel fruit extract at a dose of 2.6 mg/mice) was decreased significantly compared to control and other treatment groups (p<0.05). In conclusion, 2.6 mg/mice Kepel extract decreases sperm quality; hence, it is a potential candidate for antifertility in men.