NUCLEOPHILIC-SUBSTITUTION REACTION IN A NON-POLAR SOLVENT .4. ALKYLATION AND ACYLATION OF ACTIVE METHYLENE-COMPOUNDS USING 1,8-DIAZABICYCLO[5.4.0]UNDEC-7-ENE AS A BASE

被引：73

作者：

ONO, N

YOSHIMURA, T

SAITO, T

TAMURA, R

TANIKAGA, R

KAJI, A

机构：

[1] Department of Chemistry, Faculty of Science, Kyoto University, Sakyo-ku, Kyoto

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 1979年 / 52卷 / 06期

关键词：

D O I：

10.1246/bcsj.52.1716

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Active methylene compounds are selectively monoalkylated with alkyl halides in benzene using 1,8-diazabi-cyclo[5.4.0]undec-7-ene (DBU) as a base. Selectivity of monoalkylation decreases when the reaction is carried out in a polar solvent. Ethyl acetoacetate is O-acylated with acyl halides in the presence of DBU in acetonitrile to give the (E)-enol esters stereoselectively.

引用

页码：1716 / 1719

页数：4

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