MONITORING OF SUBSTRATES AND PRODUCTS DURING FED-BATCH PENICILLIN FERMENTATIONS ON COMPLEX MEDIA

被引：44
作者：
CHRISTENSEN, LH
NIELSEN, J
VILLADSEN, J
机构：
[1] Department of Biotechnology, Technical University of Denmark
来源：
ANALYTICA CHIMICA ACTA | 1991年 / 249卷 / 01期
关键词：
FLOW SYSTEM; BIOREACTORS; FERMENTATION; MEMBRANE MODULES; PENICILLIN FERMENTATION; PROCESS MONITORING;
D O I：
10.1016/0003-2670(91)87015-Y
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A system used for monitoring of fed-batch penicillin fermentation is characterized. The system includes exhaust gas analysers, a membrane sampling module and analysers measuring dissolved substrate components. Different membrane modules for sampling are examined and compared. An in situ sterilizable membrane module is characterized, and a model describing the now through the unit is proposed. Flow-injection analysers for measuring ammonium and glucose are described and optimized for monitoring samples from penicillin fermentation.
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页码：123 / 136
页数：14
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