INCREASED RATES OF CORTISOL PRODUCTION AND URINARY FREE CORTISOL EXCRETION IN ELDERLY WOMEN 2 WEEKS AFTER PROXIMAL FEMUR FRACTURE

被引：19

作者：

BARTON, RN ^{[1
]}

WEIJERS, JWM ^{[1
]}

HORAN, MA ^{[1
]}

机构：

[1] UNIV MANCHESTER,HOPE HOSP,DEPT GERIATR MED,SALFORD M6 8HD,LANCS,ENGLAND

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 1993年 / 23卷 / 03期

关键词：

ADRENAL CORTEX HORMONES; AGING; CREATININE; FRACTURES; WOUNDS AND INJURIES;

D O I：

10.1111/j.1365-2362.1993.tb00757.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cortisol production rate and urinary free cortisol excretion have been measured in healthy elderly women and elderly women about two weeks after upper femur fracture. Plasma cortisol was determined mid-morning, at the start of urine collection. All three variables were higher in the injured patients than in the control subjects. Urinary free cortisol excretion showed the greatest rise and was correlated with cortisol production rate in the patients. In the control subjects there was no correlation and nearly all the points fell below the regression line for the injured patients, indicating that urinary free cortisol excretion rose in relation to cortisol production rate after injury. Measurement of creatinine clearance showed that this was not due to an increased glomerular filtration rate, and a possible explanation is decreased metabolic clearance of cortisol. Plasma cortisol was not significantly correlated with either cortisol production rate or urinary free cortisol excretion.

引用

页码：171 / 176

页数：6

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