VITAMIN-K2 MODULATES PROLIFERATION AND FUNCTION OF OSTEOBLASTIC CELLS-INVITRO

被引：53

作者：

AKEDO, Y ^{[1
]}

HOSOI, T ^{[1
]}

INOUE, S ^{[1
]}

IKEGAMI, A ^{[1
]}

MIZUNO, Y ^{[1
]}

KANEKI, M ^{[1
]}

NAKAMURA, T ^{[1
]}

OUCHI, Y ^{[1
]}

ORIMO, H ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT SURG & RADIOL,TOKYO 113,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 187卷 / 02期

关键词：

D O I：

10.1016/0006-291X(92)91269-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A human osteosarcoma cell line, HOS TE85 cells, and a mouse osteoblastic cell line, MC3T3-E1 cells, were cultured for 3 days in a medium containing various concentrations of menaquinoe-4 (vitamin K2). As a result, the proliferation of HOS cells was suppressed by vitamin K2 in a dose dependent manner up to 56 % of control by 10-7M of vitamin K2 and that of MC3T3-E1 cells was suppressed to 84 % of control by 10-6M of vitamin K2. Vitamin K2 increased alkaline phosphatase activity in both kinds of cells. Warfarin counteracted the effect of vitamin K2 on osteoblastic cell proliferation. Our results show that vitamin K2 modulates proliferation and function of osteoblastic cells by some mechanisms including γ-carboxylation system. © 1992.

引用

页码：814 / 820

页数：7

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